Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway
نویسندگان
چکیده
منابع مشابه
FGF8 dose-dependent regulation of embryonic submandibular salivary gland morphogenesis.
FGF8 has been shown to play important morphoregulatory roles during embryonic development. The observation that craniofacial, cardiovascular, pharyngeal, and neural phenotypes vary with Fgf8 gene dosage suggests that FGF8 signaling induces differences in downstream responses in a dose-dependent manner. In this study, we investigated if FGF8 plays a dose-dependent regulatory role during embryoni...
متن کاملEmbryonic Salivary Gland Branching Morphogenesis
Salivary submandibular gland (SMG) morphogenesis is regulated by the functional integration of stage-specific growth factor, cytokineand transcription factor-mediated signaling which mediates specific patterns of cell proliferation, cell quiescence, apoptosis, and histodifferentiation. We describe the stage-specific distribution of protein components of key signaling pathways during embryonic S...
متن کاملRegulatory mechanisms of branching morphogenesis in mouse submandibular gland rudiments
Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial-mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators o...
متن کاملMouse submandibular gland salivary apomucin contains repeated N-glycosylation sites.
A cDNA clone encoding mouse submandibular gland salivary mucin apoprotein was isolated and characterized. The mucin cDNA encodes a protein of 273 amino acids with a calculated molecular weight of 29,606. This apomucin is approximately 60% Thr, Ser, and Pro, and has a pI of 11.25. In addition to the signal sequence, the apomucin can be divided into four structural domains. The first of these con...
متن کاملRabbit submandibular salivary gland replantation
Objectives To test the feasibility of submandibular salivary gland (SMG) replantation techniques and the survival of the replanted glands. Such a study can provide a rationale for later allotransplantation procedures, along with implementation of conventional and advanced immunosuppression therapy. Materials and Methods Six SMG replantations were performed in New Zealand white rabbits. One we...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Anatomical Record
سال: 2001
ISSN: 0003-276X,1097-0185
DOI: 10.1002/1097-0185(20010301)262:3<318::aid-ar1023>3.0.co;2-3